Moderate aortic stenosis: not as benign as it seems

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Severe aortic stenosis (AS) represents an important cause morbidity and mortality, being valve replacement the cornerstone for prognostic shift. Although mild moderate AS are regarded as low risk, its benign course has recently been challenged. Purpose to evaluate cardiovascular (CV) events identify factors in patients (pts) with AS. Methods Single center observational study pts consecutive echocardiographic evaluations, during a minimum followup (FUP) 3 years. Clinical characteristics laboratory data were collected at baseline follow-up (FUP). Analyzed FUP included pre-syncope/syncope, chest pain, dysrhythmic episodes, hospital admission due heart failure (HF), death CV death. Statistical analysis was performed using Chi-square Mann-Whitney tests. Results total 78 (74±10 years; 52.6% males), monitored mean 47±16 months. The main risk systemic arterial hypertension (83.3%), hypercholesterolemia (66.7%) diabetes (41%). Atrial fibrillation present 39.8% pts. At baseline, left ventricular ejection fraction (LVEF) 62±8,6% LV mass index (LV MI) 118±30 g/m2. FUP, NTproBNP 7879 pg/ml evaluation depicted LVEF 59±9.6% LVMI 131±36 g/m2 (table 1). 6% had 13% pain about 5% presented namely complete atrioventricular block ectopic beats. All dysrhythmias gradient greater than 30 mmHg (p = 0.030). Lower EF 0.005), MI 0.021) 0.016) right dysfunction 0.048) correlated HF (28% pts). During 29% died, 14% from cause. Greater 0.046) 0.032) worse associated death, while higher 0.034) showed correlation Conclusion Contemporary stratification is still incipient. However, less severe In our population, 1/3 died 4 years half them CDV although they didn’t progress Further investigation warranted assess whether earlier intervention could improve outcomes this subset